Oxycodone is a semisynthetic opioid synthesized from the baine, an opioid alkaloid and one of the many alkaloids found in the opium poppy. It is a moderately potent opioid pain medication, generally indicated for relief of moderate pain to severe pain as one of several semi-synthetic opioids in an attempt to improve on the existing opioids.
Uses of Oxycodone:
It is used to help relieve moderate to severe pain.
This drug belongs to a class of drugs known as opioid (narcotic) analgesics.
It works in the brain to change how your body feels and responds to pain.
Side Effects of using Oxycodone:
Nausea and vomiting.
It is a semisynthetic derivative of codeine that acts as a narcotic analgesic more potent and addicting than codeine. An extended-release (ER) form of oxycodone (Xtampza ER) was approved for the management of daily, around-the-clock pain management in April, 2016.
Oxycodone, is similar to other phenanthrene derivatives such as hydrocodone and morphine. It is available in combination with aspirin or acetaminophen to control pain and restless leg and Tourette syndromes.
Mechanism of Action of Oxycodone:
Oxycodone acts as a weak agonist at mu, kappa, and delta opioid receptors within the central nervous system (CNS). It primarily affects mu-type opioid receptors, which are coupled with G-protein receptors and function as modulators, both positive and negative, of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex.
As the effector system is adenylate cyclase and CAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine, and noradrenaline is inhibited.
Opioids such as oxycodone also inhibit the release of vasopressin, somatostatin, insulin, and glucagon. Opioids close N-type voltage-operated calcium channels (kappa-receptor agonist) and open calcium-dependent inwardly rectifying potassium channels (mu and delta receptor agonist). This results in hyperpolarization and reduced neuronal excitability.
Symptoms of overdose include respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, bradycardia, hypertension, and death.
How Should I take Oxycodone:
If you are taking the the extended-release tablets, swallow them whole; do not chew, break, divide, crush, or dissolve them.
Do not presoak, lick or otherwise wet the tablet prior to placing in the mouth. Swallow each tablet right after you put it in your mouth.
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